How to destroy bacterial biofilms with high productivity?

PATENT:

2789544

INVENTION:

Nucleotide sequence encoding β-N-acetylhexosaminidase Aggregatibacter actinomycetemcomitans, and genetic constructs containing it

PATENTEE:

LLC “Innova plus”

PURPOSE:

for destruction of bacterial biofilms with the use of enzymes

INNOVATION:

Bacteria surrounded by a protective layer, a surface biofilm, are a hundred times more resistant to their environment than free-living microorganisms. Such bacteria show much higher resistance to antibiotics and other medicines, which makes it extremely difficult to fight infections caused by various pathogenic bacteria. About 65-80% of all infectious lesions are caused by biofilm-forming bacteria. At present, there are various methods of combating biofilms but the promising ones are the biological methods of destruction of biofilms with the use of enzymes. In this regard, a nucleic acid for the production of a biofilm-destroying enzyme has been obtained. The activity of the obtained enzyme is 7 times higher than the activity needed for the destruction of biofilms.

SCOPE OF
APPLICATION:

The invention relates to the field of biotechnology.

For more details please refer to the published patent.